Vivitrol Treatment for Addiction: What to Expect and Who It’s For

Vivitrol is one of several FDA-approved medications used to support addiction recovery, but it works differently from many other options. Instead of activating opioid and alcohol receptors, it blocks them entirely.

For people exploring recovery after detox, understanding what Vivitrol is and how it works can help determine whether it’s the right fit. Unlike some forms of medication-assisted treatment (MAT), Vivitrol does not contain opioids and does not carry a risk of dependence. This guide explains how the Vivitrol shot works, who it’s for, and what treatment looks like at Painted Grove Recovery in Louisville, Kentucky.

What is Vivitrol?

So, what is Vivitrol? Vivitrol is the brand name for extended-release naltrexone, a medication given as a once-monthly injection. It is FDA-approved to treat both opioid use disorder and alcohol use disorder. The Vivitrol injection works by blocking opioid receptors in the brain. These receptors are responsible for the “reward” feeling people experience when using substances like opioids or alcohol.

As a result, opioids no longer produce a high, alcohol becomes less rewarding, and cravings are reduced over time. This makes Vivitrol a powerful option for people committed to maintaining sobriety.

How Vivitrol works

Vivitrol is classified as an opioid antagonist, meaning it blocks opioid receptors without activating them.

It reduces cravings and makes using opioids less rewarding by reducing the “reward” response in the brain associated with substance use. Unlike Suboxone or Subutex, Vivitrol contains no opioids and carries no risk of dependence. This makes it a strong option for individuals who want a non-addictive approach to recovery.

Vivitrol for opioid addiction

Vivitrol is commonly used after detox for opioid addiction. Before starting Vivitrol treatment, a person must be fully detoxed and opioid-free for 7 to 10 days before starting Vivitrol. This is important because taking Vivitrol too soon can trigger withdrawal symptoms. Once Vivitrol is started, it blocks the effects of opioids, so if someone uses opioids, they will not feel the usual high. This makes it especially effective for people committed to abstinence and looking to prevent relapse after detox.

Vivitrol for alcohol addiction

Vivitrol for alcohol use disorder works differently than it does for opioids, but it is equally effective.

It reduces cravings and disrupts the reward center in the brain, making drinking alcohol less pleasurable or rewarding. For alcohol addiction, detox is not always required before starting Vivitrol. As part of MAT for alcohol, Vivitrol is typically combined with therapy and support groups to improve long-term recovery and reduce relapse risk.

Vivitrol vs. Suboxone

A common question in recovery is how Vivitrol compares to Suboxone. Vivitrol is an opioid antagonist (blocks receptors) while Suboxone is a partial agonist (activates receptors slightly). Vivitrol requires a full detox from opioids before starting and is given by monthly injection and carries no risk of opioid dependence. Suboxone can be started during early withdrawal and is taken as a daily medication and carries a low risk of dependence. Determining which medication is the right choice depends on your medical history and stage of recovery.

Vivitrol side effects

Like any medication, side effects are possible, though most are mild. Common Vivitrol side effects include:

• Nausea
• Headache
• Fatigue
• Dizziness
• Injection site soreness

Symptoms often improve after the first injection as the body adjusts. A nurse monitors for side effects, and a physician, nurse practitioner, or other authorized prescriber can adjust the treatment plan if needed.

What is medication-assisted treatment?

Medication-assisted treatment (MAT) combines FDA-approved medications, like Vivitrol, with therapy and behavioral support. This approach reduces cravings and relapse risk, addresses both physical and psychological aspects of addiction, and supports long-term recovery. MAT is widely recommended by organizations like SAMHSA and the American Medical Association as one of the most effective treatments for opioid and alcohol use disorders.

Frequently asked questions

Can you drink on Vivitrol?

While it is physically possible to drink on Vivitrol, the medication reduces the pleasurable effects of alcohol, making drinking less appealing and helping support sobriety.

How long does a Vivitrol shot last?

Each Vivitrol shot lasts about 28 to 30 days. Most people receive the injection once a month as part of their treatment plan.

Is Vivitrol addictive?

No. Vivitrol contains no opioids and does not activate opioid receptors, so there is no risk of dependence or misuse.

How long do you stay on Vivitrol?

The length of treatment varies. Some people stay on Vivitrol for several months, while others continue for a year or longer, depending on their recovery progress.

Does insurance cover Vivitrol?

Your plan or Kentucky Medicaid may cover Vivitrol treatment. Our admissions team can verify your benefits and explain costs before treatment begins.

Vivitrol treatment at Painted Grove Recovery

At Painted Grove Recovery, Vivitrol treatment is offered as part of a comprehensive treatment program in Louisville, Kentucky. As part of our programs, clients receive:

• Medical evaluation to determine if Vivitrol is the right fit
• Support transitioning from detox into Vivitrol treatment
• Coordination for ongoing Vivitrol care after discharge — Painted Grove Recovery does not offer outpatient Vivitrol maintenance or monthly injection visits
• Therapy and group support alongside medication

The clinical team takes an individualized approach, ensuring each person receives care tailored to their needs and recovery goals. If you have questions about cost or coverage, you can explore your options for paying for treatment.

If you’re considering Vivitrol, reaching out for an assessment can help you decide if it’s the right next step. Reach out to our admissions team today.

• Medication-Assisted Treatment